US public-data layer added to AIRCHILL clinical development
MedicalCooling has added a new source-governed US clinical-development data layer. The update separates observed CMS Medicare hospital utilization and payments from ClinicalTrials.gov research-network signals, AIRCHILL trial observations and health-economic model assumptions.
For stroke, CMS cerebrovascular MS-DRG data are now used only as first-pass hospital burden and payer-context signals. Candidate centres must then be qualified for LVO/EVT volume, clinically indicated general anaesthesia and invasive ventilation, workflow timing, competing trials and expected randomisations per centre-month.
For cardiac arrest, the programme now explicitly prohibits using MS-DRG 296 as an OHCA incidence or recruitment proxy. US recruitment planning is EMS-catchment first and tracks OHCA through sustained ROSC, unconscious status, ventilation, protocol timing, exclusions and randomisation. ClinicalTrials.gov is used to identify active resuscitation research networks for deeper qualification.
For TBI and concussion, severe inpatient TBI DRGs can identify neurotrauma centres for future portfolio research, while sparse concussion inpatient data are explicitly treated as unsuitable for estimating the broader concussion burden.
The clinical protocols, screening plan, CRF/data dictionary and pivotal-trial cost model have been updated to use the same observed-versus-modelled data architecture.