AIRCHILL US Clinical & Public Data Intelligence
Public-data intelligence · CMS + ClinicalTrials.gov · v1.0 · 4 September 2026
US clinical-development intelligence built from observed public data.
This page separates observed US public-healthcare data from AIRCHILL assumptions. It uses CMS Medicare aggregate hospital records to identify burden, payment and hospital-volume signals; ClinicalTrials.gov to identify current research-network activity; and protocol-specific feasibility data before any site, market-size or recruitment conclusion is made.
Decision architecture
One source is never enough for site selection or market sizing.
CMS hospital data
Hospital × MS-DRG discharges, submitted covered charges, total payments and Medicare payments. Use: burden signal, payer context and first-pass hospital screening.
Research-network activity
ClinicalTrials.gov investigator and site activity. Use: evidence that a centre or EMS network is currently participating in relevant research; not proof that it is suitable for AIRCHILL.
Protocol feasibility
EVT volume, general-anaesthesia fraction, OHCA ROSC flow, airway timing, consent pathway, device workflow, competing trials and randomisations per centre-month must be measured prospectively before pivotal site lock.
Observed vs modelled
CMS observed payments remain separate from AIRCHILL outcome scenarios, QALY/DALY modelling, ICU/rehabilitation assumptions and projected savings.
Stroke · first-pass US site intelligence
Use DRGs 061–066 as broad cerebrovascular burden signals — not as LVO/EVT counts.
For the 2024 CMS Medicare inpatient dataset, DRGs 064–066 cover intracranial haemorrhage or cerebral infarction by complication level; DRGs 061–063 cover ischemic stroke/precerebral occlusion/transient ischemia with thrombolytic agent. The AIRCHILL-STROKE target is narrower: anterior-circulation LVO selected for EVT with clinically indicated general anaesthesia and invasive ventilation. Therefore CMS volume is only Stage 1 of screening.
Published hospital-DRG rows in the 2024 dataset for intracranial haemorrhage or cerebral infarction with MCC. CMS suppresses rows with ≤10 discharges.
Published hospital-DRG rows for intracranial haemorrhage or cerebral infarction with CC or tPA in 24 hours.
Published hospital-DRG rows for intracranial haemorrhage or cerebral infarction without CC/MCC.
Published hospital-DRG rows for the MCC stratum of ischemic stroke/precerebral occlusion/transient ischemia with thrombolytic agent.
| Example centre from CMS returned ranked pages | 2024 signal | Observed average Medicare payment | Why it matters |
|---|---|---|---|
| AdventHealth Orlando | DRG 064: 320 discharges; DRG 065: 238; DRG 061: 20 | DRG 064: $12,451; DRG 065: $6,390; DRG 061: $21,289 | Consistent high cerebrovascular signal across multiple CMS strata; requires EVT/GA and competing-trial qualification before use as a recruitment estimate. |
| NewYork-Presbyterian Hospital | DRG 064: 226; DRG 065: 174; DRG 061: 19 | DRG 064: $25,079; DRG 065: $10,724; DRG 061: $32,406 | Large CMS signal plus current acute-stroke research activity in the NewYork-Presbyterian/Weill Cornell ecosystem on ClinicalTrials.gov. |
| ChristianaCare | DRG 064: 195; DRG 065: 222; DRG 066: 63; DRG 061: 18 | DRG 064: $15,465; DRG 065: $7,170; DRG 066: $4,454; DRG 061: $21,232 | Broad observed stroke burden across complication strata; candidate for deeper EVT-capability and study-workflow screening. |
| Inova Fairfax Hospital | DRG 064: 187; DRG 061: 15 | DRG 064: $16,243; DRG 061: $22,083 | Useful dual stroke/TBI public-data signal; requires protocol-specific site feasibility. |
| Massachusetts General Hospital | DRG 064: 181 | DRG 064: $19,889 | Appears in current US acute-ischemic-stroke trial activity on ClinicalTrials.gov; research activity strengthens — but does not establish — site candidacy. |
AIRCHILL-STROKE site score
The working site score is now a staged qualification framework rather than a single volume rank:
20% CMS cerebrovascular signal20% EVT / LVO volume15% GA + invasive-ventilation eligible fraction15% active stroke-trial capability10% door-to-puncture workflow10% consent / emergency research readiness10% expected randomisations per centre-month
Cardiac arrest · prevent a major denominator error
DRG 296 is not an OHCA market-size proxy.
In the 2024 CMS inpatient dataset, DRG 296 (“cardiac arrest, unexplained with MCC”) produced only five published hospital rows after CMS suppression of cells with 10 or fewer discharges. The returned values ranged from 11 to 15 discharges. That is useful as a narrow reimbursement observation, but it plainly cannot represent total OHCA or post-resuscitation hospital burden.
Use DRG 296 only as observed billing data
Never extrapolate national OHCA incidence, AIRCHILL eligibility or recruitment directly from this DRG.
Build the denominator outside the DRG
OHCA incidence → attempted resuscitation → sustained ROSC → unconscious → invasive ventilation → protocol timing → exclusions → randomisation.
Screen EMS research capability
ClinicalTrials.gov currently identifies US OHCA research activity including King County EMS, Hennepin Healthcare Research Institute and University of Pittsburgh emergency-medicine investigators/networks.
Link outcomes to resource use
Observed inpatient payments are anchors; disability, rehabilitation, long-term care and survival/QALY scenarios remain separate model layers.
TBI & concussion · portfolio intelligence
Severe TBI is visible in inpatient CMS data; mild concussion often is not.
FY2024 MS-DRGs 082–087 classify traumatic stupor/coma by duration and complication level; 088–090 classify concussion. This creates a useful public-data split: severe TBI can support hospital-volume screening, while mild concussion requires outpatient/ED/epidemiologic sources because inpatient cells are sparse and suppressed.
Published 2024 hospital-DRG rows for traumatic stupor/coma >1 hour with MCC.
Only one published 2024 hospital row for concussion with MCC met the CMS publication threshold in this query — a strong warning against using inpatient CMS to size concussion burden.
Vanderbilt University Medical Center discharges; average Medicare payment about $17,769.
ClinicalTrials.gov returned 308 US TBI studies in the current search universe, with 25 analysed in the first result batch and multiple active research sites.
| DRG 082 example | 2024 discharges | Average Medicare payment | Interpretation |
|---|---|---|---|
| Vanderbilt University Medical Center | 61 | $17,769 | Strong severe-TBI inpatient signal; also appears in active US stroke research networks. |
| Memorial Hermann Texas Medical Center | 57 | $23,627 | High severe-TBI signal and active acute-stroke research ecosystem. |
| Westchester Medical Center | 55 | $25,914 | High published Medicare severe-TBI signal. |
| Inova Fairfax Hospital | 54 | $20,515 | Cross-indication neuro-emergency signal in the public data. |
| NewYork-Presbyterian Hospital | 48 | $30,901 | High-acuity TBI signal plus active neurovascular research ecosystem. |
Health economics
Every economic claim now has a declared layer.
CMS
Published discharges, submitted covered charges, total payments and Medicare payments, with reporting year, row grain and suppression caveat.
AIRCHILL clinical data
mRS/CPC, mortality, ICU and hospital days, ventilation, rehabilitation discharge, EQ-5D-5L and resource use collected prospectively.
Outcome improvement
Prespecified +1/+3/+5 percentage-point or trial-derived outcome scenarios. These remain explicitly labelled assumptions until AIRCHILL clinical data replace them.
Long-term value
QALYs, lifetime costs, rehabilitation, long-term care, productivity and payer-budget impact with sensitivity analysis.
Data refresh & provenance
Public-data pages are versioned, not treated as timeless facts.
- CMS Medicare Inpatient Hospitals: reporting year 2024; dataset modification/publication used here: 23 April 2026; historical coverage available in the connector from 2013–2024.
- CMS suppression: provider-DRG records with 10 or fewer discharges are excluded from the published hospital-DRG results.
- ClinicalTrials.gov: registry activity is a research-capability signal, not proof of quality, eligibility or willingness to participate in AIRCHILL.
- Refresh trigger: a new complete CMS reporting year, a material ClinicalTrials.gov network change, or a protocol version change triggers review of affected tables and site scores.
- Change control: preserve the prior reporting year and document source date, methodology change and affected conclusions in the website change history.
Primary public sources
CMS Medicare Inpatient Hospitals – by Provider and Service →
CMS 2024 DRG 064 query →
CMS 2024 DRG 065 query →
CMS 2024 DRG 066 query →
CMS 2024 DRG 061 query →
CMS 2024 DRG 296 query →
CMS 2024 DRG 082 query →
ClinicalTrials.gov acute ischemic stroke search →
ClinicalTrials.gov OHCA search →
ClinicalTrials.gov TBI search →
Public CMS aggregate data do not contain patient-level records and are not medical advice, a coverage determination or government endorsement. Site examples are screening candidates only.